Thierry Facon Selected Research

Thalidomide (Thalomid)

10/2021	Maintenance with daratumumab or observation following treatment with bortezomib, thalidomide, and dexamethasone with or without daratumumab and autologous stem-cell transplant in patients with newly diagnosed multiple myeloma (CASSIOPEIA): an open-label, randomised, phase 3 trial.
1/2021	Front-line daratumumab-VTd versus standard-of-care in ASCT-eligible multiple myeloma: matching-adjusted indirect comparison.
1/2021	Stem cell yield and transplantation in transplant-eligible newly diagnosed multiple myeloma patients receiving daratumumab + bortezomib/thalidomide/dexamethasone in the phase 3 CASSIOPEIA study.
12/2020	Continuous lenalidomide and low-dose dexamethasone in patients with transplant-ineligible newly diagnosed MM: FIRST trial subanalysis of Canadian/US patients.
1/2019	Bortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open-label, phase 3 study.
1/2018	Final analysis of survival outcomes in the phase 3 FIRST trial of up-front treatment for multiple myeloma.
3/2017	Continuous treatment with lenalidomide and low-dose dexamethasone in transplant-ineligible patients with newly diagnosed multiple myeloma in Asia: subanalysis of the FIRST trial.
1/2017	A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation.
10/2016	Updated Outcomes and Impact of Age With Lenalidomide and Low-Dose Dexamethasone or Melphalan, Prednisone, and Thalidomide in the Randomized, Phase III FIRST Trial.
3/2016	Impact of renal impairment on outcomes with lenalidomide and dexamethasone treatment in the FIRST trial, a randomized, open-label phase 3 trial in transplant-ineligible patients with multiple myeloma.

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Thierry Facon Research Topics

Disease

155	Multiple Myeloma 10/2022 - 01/2002
24	Disease Progression 10/2022 - 06/2005
16	Neoplasms (Cancer) 09/2021 - 03/2002
11	Peripheral Nervous System Diseases (PNS Diseases) 10/2021 - 03/2009
8	Residual Neoplasm 01/2022 - 12/2016
8	Infections 01/2021 - 01/2006
7	Pneumonia (Pneumonitis) 11/2021 - 01/2016
7	Neutropenia 11/2021 - 11/2007
7	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 03/2007 - 02/2002
6	Thrombocytopenia (Thrombopenia) 11/2020 - 11/2007
5	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 11/2005
4	Frailty 01/2022 - 01/2020
4	Lymphopenia (Lymphocytopenia) 11/2021 - 01/2019
4	Hypertension (High Blood Pressure) 10/2021 - 01/2016
4	Fatigue 11/2020 - 02/2003
4	Anemia 01/2019 - 01/2006
4	Chromosome Aberrations (Chromosome Abnormalities) 01/2018 - 03/2002
3	Pain (Aches) 10/2021 - 05/2002
3	Heart Failure 09/2019 - 02/2003
3	Heart Arrest (Cardiac Arrest) 09/2019 - 10/2017
3	Neoplasm Metastasis (Metastasis) 04/2008 - 02/2003
3	Breast Neoplasms (Breast Cancer) 01/2008 - 02/2003
3	Bone Resorption 02/2006 - 05/2002
2	Septic Shock (Toxic Shock Syndrome) 10/2021 - 10/2017
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2021 - 08/2002
2	Carcinogenesis 01/2020 - 09/2002
2	Vomiting 01/2019 - 03/2012
2	Agammaglobulinemia (Hypogammaglobulinemia) 01/2019 - 06/2008
2	Lymphoma (Lymphomas) 04/2016 - 11/2005
2	Plasma Cell Leukemia 01/2016 - 03/2002
2	Venous Thromboembolism 10/2013 - 11/2007
2	Paraproteinemias (Monoclonal Gammopathy) 03/2013 - 03/2002
2	Constipation 05/2012 - 03/2012
2	Herpes Zoster 10/2008 - 02/2003
2	Waldenstrom Macroglobulinemia (Macroglobulinemia) 06/2008 - 06/2008
2	Osteonecrosis (Kienbock's Disease) 04/2008 - 01/2008
2	Monoclonal Gammopathy of Undetermined Significance 10/2007 - 10/2005
2	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 01/2007 - 10/2003
1	Bites and Stings (Sting) 10/2020
1	Amyloidosis 01/2020
1	Respiratory Insufficiency (Respiratory Failure) 09/2019
1	Myocarditis (Carditis) 09/2019

Drug/Important Bio-Agent (IBA)

73	Dexamethasone (Maxidex)FDA LinkGeneric 06/2022 - 06/2005
51	Bortezomib (Velcade)FDA Link 01/2022 - 06/2005
42	Lenalidomide (CC 5013)FDA Link 01/2022 - 11/2007
29	Thalidomide (Thalomid)FDA Link 10/2021 - 01/2002
24	Melphalan (Alkeran)FDA LinkGeneric 01/2022 - 02/2002
18	Prednisone (Sone)FDA LinkGeneric 01/2022 - 03/2002
14	daratumumabIBA 10/2022 - 01/2019
14	carfilzomibIBA 06/2022 - 05/2015
12	pomalidomideIBA 01/2022 - 03/2013
8	Proteasome InhibitorsIBA 11/2020 - 11/2005
8	Imatinib Mesylate (Gleevec)FDA Link 10/2011 - 02/2002
7	isatuximabIBA 10/2022 - 01/2021
7	selinexorIBA 10/2021 - 01/2019
7	Pharmaceutical PreparationsIBA 10/2021 - 05/2002
6	Immunomodulating AgentsIBA 01/2020 - 11/2010
6	Biological ProductsIBA 01/2017 - 03/2002
5	Monoclonal AntibodiesIBA 06/2022 - 05/2016
5	Biomarkers (Surrogate Marker)IBA 12/2021 - 02/2003
4	B-Cell Maturation AntigenIBA 01/2022 - 01/2020
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2016
4	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/2018 - 08/2013
4	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2016 - 02/2003
4	Immunoglobulins (Immunoglobulin)IBA 12/2014 - 03/2002
4	Proteasome Endopeptidase Complex (Proteasome)IBA 03/2009 - 11/2005
3	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2018 - 07/2014
3	Diphosphonates (Bisphosphonates)IBA 04/2008 - 05/2002
3	bcr-abl Fusion ProteinsIBA 12/2003 - 02/2002
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/2003 - 08/2002
2	Chimeric Antigen ReceptorsIBA 01/2022 - 12/2019
2	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA 01/2022 - 10/2021
2	ixazomibIBA 01/2022 - 01/2021
2	venetoclaxIBA 01/2021 - 11/2017
2	elotuzumabIBA 12/2015 - 06/2012
2	Immunologic Factors (Immunomodulators)IBA 01/2013 - 12/2012
2	Immunoglobulin M (IgM)IBA 06/2008 - 06/2008
2	AlbuminsIBA 10/2007 - 02/2003
2	HLA-G Antigens (HLA G)IBA 10/2005 - 10/2003
2	OsteoprotegerinIBA 06/2005 - 02/2003
2	Cytarabine (Cytosar-U)FDA LinkGeneric 12/2003 - 04/2003
1	idecabtagene vicleucelIBA 01/2022
1	VaccinesIBA 12/2021
1	PENTAIBA 09/2021
1	vendexIBA 01/2021
1	Exportin 1 ProteinIBA 01/2021
1	vasectrin IIIIBA 01/2020
1	Immunoconjugates (Immunoconjugate)IBA 01/2020
1	belantamab mafodotinIBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020

Therapy/Procedure

66	Therapeutics 10/2022 - 01/2002
24	Stem Cell Transplantation 11/2021 - 02/2002
11	Drug Therapy (Chemotherapy) 11/2021 - 05/2002
9	Transplantation 01/2022 - 05/2007
2	Salvage Therapy 05/2012 - 06/2009
2	Radiotherapy 02/2003 - 05/2002
1	Retreatment 10/2021
1	Palliative Care (Palliative Therapy) 01/2021
1	Precision Medicine 01/2020
1	Intravenous Infusions 01/2020